Effectiveness of Ozone Gas on Airborne Virus Inactivation in Enclosed Spaces:
A Review Study
Mahmood Alimohammadi a,b and Maziar Naderia,c
ABSTRACT
Due to the recent outbreak of COVID-19, the problem of protecting the individual against airborne
transmission has become of great importance. This transmission occurs when virus-containing
droplets enter the respiratory tract. Accordingly, the inactivation of airborne viruses plays significant role in mitigating the threat posed by a human-to-human infectious disease. The use of gasbased treatments such as ozone to decontaminate indoor air containing viruses has been increased.
Ozone is a strong oxidizing agent that can be used to inactivate broad-range viruses that might be
resistant to other disinfectants. The purpose of the study is to bring attention to the ozonizing of
indoor air as a novel treatment for the inactivation of viruses. This review study showed that
enveloped viruses (e.g., SARS-CoV-2) are more sensitive to oxidizing agents such as ozone than
to non-enveloped viruses. Furthermore, some viruses such as coronaviruses have cysteine containing a sulfhydryl group that reacts with ozone gas. The study indicated that more free radicals will be
formed when air humidity is higher, which could lead to higher virus inactivation. Air disinfection by
ozone gas can be a promising approach for the viral deactivation of contaminated spaces in
hospitals, health-care centers, dental offices, sport clubs, hotels and transportation sector, as well
as all other places where viral disease outbreaks occur.
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